质量水平
方案
≥97% (HPLC)
表单
solid
制造商/商品名称
Calbiochem®
储存条件
OK to freeze
protect from light
颜色
yellow
溶解性
DMSO: 200 mg/mL
储存温度
−20°C
SMILES字符串
Brc1cc(ccc1)Nc2ncnc3c2cc(cc3)NC(=O)CC
InChI
1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22)
InChI key
WUPUZEMRHDROEO-UHFFFAOYSA-N
一般描述
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 450 pM). The reversible nature of this compound makes it a less effective antitumor agent than PD 168393 (Cat. No. 513033).
生化/生理作用
Primary Target
EGFR tyrosine kinase activity
EGFR tyrosine kinase activity
Target IC50: 450 pM against EGF receptor (EGFR) tyrosine kinase activity
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Fry, D.W., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 12022.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
495.3 °F
闪点(°C)
257.4 °C
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