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520222

PPACK dihydrochloride

Name: PPACK dihydrochloride
Brand: MM

≥80% (HPLC), solid, thrombin inhibitor, Calbiochem^®

Synonym(s):

PPACK, Dihydrochloride

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About This Item

CAS Number:

82188-90-7

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥80% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated, protect from light

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Properties

Product Name

PPACK, Dihydrochloride, PPACK, Dihydrochloride is an extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M⁻¹S⁻¹). Reacts with thrombin in a 1:1 stoichiometry.

description

Merck USA index - 14, 7699

Quality Level

100

assay

≥80% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

water: 100 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

ClCC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)Cc2ccccc2)CCCN=C(N)N.Cl.Cl

Description

General description

Extremely potent and selective irreversible inhibitor of thrombin (K_obs/[I] = 10⁷M^-1S^-1). Reacts with thrombin in a 1:1 stoichiometry. Can also be used to inhibit tissue plasminogen activator, Factor VIIa, and Factor XIa. Also available as a 25 mM solution in H₂O (Cat. No. 508773 ).

Biochem/physiol Actions

Cell permeable: no

Kobs/[I] = 107 M⁻¹ sec⁻¹ as inhibitor of thrombin

Primary Target
Thrombin

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions (pH <4) are stable for up to 4 months at -20°C. Rapidly decomposes at an alkaline pH.

Other Notes

H-D-Phe-Pro-Arg-chloromethylketone, 2HCl

Rosado, J. A., et al. 2002. J. Biol. Chem.277, 42157.
Odake S., et al. 1995. J. Enzyme Inhib.9, 17.
Arni, R.K., et al. 1993. Biochemistry 32, 4727.
Yamashita, T., et al. 1993. Thromb. Res. 69, 93.
Schmaier, A.H., et al. 1992. Thromb. Res.67, 479.
Collen, D., et al. 1982. J. Lab. Clin. Med.99, 76.
Kettner, C., and Shaw, E. 1981. Methods Enzymol.80, 826.
Kettner, C., and Shaw, E. 1979. Thromb. Res.14, 969.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c