Key Documents

View All Documentation

527455

PKR Inhibitor, Negative Control

Name: PKR Inhibitor, Negative Control
Brand: MM

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₅H₈Cl₃NO₂

CAS Number:

852547-30-9

Molecular Weight:

340.59

MDL number:

MFCD09037552

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (sum of two isomers, HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

≥95% (sum of two isomers, HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL, ethanol: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1c(c(cc(c1)C=C2c3c(ccc(c3)Cl)NC2=O)Cl)O

InChI

1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)

InChI key

ZJFMARHFPUZEKI-UHFFFAOYSA-N

Description

General description

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC₅₀ >100 µM) or in rescuing PKR-dependent translation block.

Biochem/physiol Actions

Cell permeable: no

Primary Target
A negative control for PKR Inhibitor

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Other Notes

Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues.

Sanket S Ponia et al.

Cell reports, 37(4), 109888-109888 (2021-10-28)

Dysregulated inflammation dominated by chemokine expression is a key feature of disease following infection with the globally important human pathogens Zika virus (ZIKV) and dengue virus, but a mechanistic understanding of how pro-inflammatory responses are initiated is lacking. Mitophagy is

Global Trade Item Number

SKU	GTIN
527455-10MG	04055977270389