528245
PLD Inhibitor, FIPI
The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.
Synonym(s):
PLD Inhibitor, FIPI, Compound 4k, PLD Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C23H24FN5O2
CAS Number:
Molecular Weight:
421.47
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥99% (HPLC)
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3
General description
A cell-permeable, PLD1/2 inhibitor (IC50 = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC50 = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.
Packaging
Packaged under inert gas
Other Notes
Su, W., et al. 2009. Mol Pharmacol75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.
Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Ruth Ndathe et al.
Frontiers in plant science, 15, 1356699-1356699 (2024-04-29)
Core protein components of the abscisic acid (ABA) signaling network, pyrabactin resistance (PYR), protein phosphatases 2C (PP2C), and SNF1-related protein kinase 2 (SnRK2) are involved in the regulation of stomatal closure and gene expression downstream responses in Arabidopsis thaliana. Phosphatidic
Syed S Hussain et al.
Cell reports, 36(4), 109451-109451 (2021-07-29)
Lipid droplets (LDs) are dynamic organelles that undergo dynamic changes in response to changing cellular conditions. During nutrient depletion, LD numbers increase to protect cells against toxic fatty acids generated through autophagy and provide fuel for beta-oxidation. However, the precise
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 528245-5MG | 04055977196559 |