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Merck
CN

5.31038

TAT-Beclin-1, Scrambled

≥95% (HPLC), powder, Beclin-1 activator, Calbiochem®

Synonym(s):

Beclin-1 Activator I, TAT-Beclin-1, Scrambled, H₂N-YGRKKRRQRRR-GG-VGNDFFINHETTGFATEW-CO2H

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About This Item

Empirical Formula (Hill Notation):
C164H251N57O45
Molecular Weight:
3741.10
UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

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Product Name

Beclin-1 Activator I, TAT-Beclin-1, Scrambled,

assay

≥95% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

water: 25 mg/mL

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: yes
Reversible: yes

Disclaimer

Toxicity: Standard Handling (A)

General description

Beclin-1 (267-284), a randomly shuffled peptideis made cell-permeable by attaching covalently to a human immunodeficiency virus(HIV)-1 Tat protein transduction domain via a diglycine linker. Beclin-1activating peptide I, TAT-Beclin-1, is observed to promote autophagy invitro and in vivo in pharmacological research.

Other Notes

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg~Gly-Gly~Val-Gly-Asn-Asp-Phe-Phe-Ile-Asn-His-Glu-Thr-Thr-Gly-Phe-Ala-Thr-Glu-Trp-OH
Liu, Y., et al. 2013. Proc. Natl. Acad. Sci. USA110, 20364.
Shoji-Kawata, S., et al. 2013. Nature.494, 201.

Packaging

Packaged under inert gas

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

新产品
This item has

Certificates of Analysis (COA)

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Beclin-1-Dependent Autophagy Improves Outcomes of Pneumonia-Induced Sepsis
Azadeh N, et al.
Frontiers in Cellular and Infection Microbiology (2021)

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