5.31709
Apoptosis Activator IX, DPP-23
Synonym(s):
Apoptosis Activator IX, DPP-23, Unfolded Protein Response Inducer, DPP-23, UPR Inducer, DPP_23
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About This Item
Empirical Formula (Hill Notation):
C18H18O4
CAS Number:
Molecular Weight:
298.33
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
General description
A cell-permeable chalcone derivative that enhances the production of reactive oxygen species and reduces glutathione levels selectively in cancer cells while sparing normal cells and induces unfolded protein response (UPR) through up-regulating UPR related genes. Inhibits the growth of in multiple cancer cell lines (Capan-1, MDA-MB231, HCT116, and HT1080 cells) and suppresses the growth of HCT116 tumor xenografts in nude mice via the induction of apoptosis (10 mg/kg, i.p; q.d.). Arrests cell cycle at the G2/M phase and triggers protective autophagy and induces apoptosis by increasing the active forms of caspase 3, 7, and 9. Treatment of serum-starved MIA PaCa-2 cells with DPP-23 induces the phosphorylation of ERK1/2, JNK1/2, and p38 MAPK in a time-dependent manner.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Please note that the molecular weight for this compound is batch-specific due to variable water content.
Biochem/physiol Actions
Cell permeable: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Shin, Y.S., et al. 2014. Clin. Cancer Res.20, in press.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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