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5.32586

AEBSF hydrochloride

≥99% (HPLC), powder, serine protease inhibitor, Calbiochem®

Synonym(s):

AEBSF, HCl ≥99% by HPLC, 4-(2-Aminoethyl)benzenesulfonylfluoride, HCl, 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride, HCl

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About This Item

Empirical Formula (Hill Notation):
C8H10FNO2S · xHCl
CAS Number:
30827-99-7
Molecular Weight:
203.23 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00132962
Assay:
≥99% (HPLC)
Form:
powder
Storage condition:
OK to freeze, desiccated, protect from light
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Product Name

AEBSF, HCl ≥99% by HPLC,

assay

≥99% (HPLC)

Quality Segment

100

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated, protect from light

color

white

solubility

H2O: 50 mg/mL

storage temp.

2-8°C

SMILES string

F[S](=O)(=O)c1ccc(cc1)CCN.[Cl-].[H+]

InChI

1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

InChI key

WRDABNWSWOHGMS-UHFFFAOYSA-N

General description

AEBSF >99%; 30827-99-7
Specific irreversible inhibitor of serine proteases. Reacts covalently with a serine at the active site. Inhibits chymotrypsin, kallikrein, plasmin, thrombin, trypsin, and related thrombolytic enzymes. Stable, nontoxic alternative to PMSF (Cat. No. 52332). Used at the same molar concentration (0.1-1.0 mM) as PMSF for most applications. Exhibits low inhibitory activity towards proteinase K. A material with ≥97% purity by HPLC (Cat. No. 101500) & its InSolution is also available (Cat. No. 508436).Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
Serine proteases
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Citron, M., et al. 1996. Neuron17, 171.

Ohkubo, I., et al. 1994. J. Biochem.116, 1182.

Mintz, G.R. 1993. BioPharm.6, 34.

Lawson, W.B., et al. 1982. Folia Haematol.109, 52.

Markwardt, F., et al. 1974. Biochem. Pharmacol.23, 2247.
Markwardt, F., et al. 1973. Thromb. Res.2, 343.
Baker, B.R., and Cory, M. 1971. J. Med. Chem.14, 119.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Corrosive (L)

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pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1A

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

8A - Combustible corrosive hazardous materials

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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