5.33761
HSF1 Activator HSF1A
Synonym(s):
HSF1 Activator HSF1A, Heat Shock Factor 1 Activator, HSF1A
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About This Item
Empirical Formula (Hill Notation):
C21H19N3O2S2
CAS Number:
Molecular Weight:
409.52
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
off-white
solubility
DMSO: 50 mg/mL
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(Nc2[n](nc(c2)c4[s]ccc4)c3ccccc3)c1ccc(cc1)CC
InChI
1S/C21H19N3O2S2/c1-2-16-10-12-18(13-11-16)28(25,26)23-21-15-19(20-9-6-14-27-20)22-24(21)17-7-4-3-5-8-17/h3-15,23H,2H2,1H3
InChI key
KJTITGSAONQVPY-UHFFFAOYSA-N
General description
A cell-permeable pyrazolylsulfonamide compound that activates heat shock factor 1 (HSF1) and protects mammalian cells against stress-induced apoptosis. Offers protection against ER stress-induced apoptosis as indicated by blunting of caspase-3 activity in treated cells. Shown to activate human HSF1 function in yeast cells. Promotes the nuclear localization and phosphorylation of HSF1 (within 2 h of treatment). Activates Hsp25 and Hsp70 expression in wild-type mouse embryonic fibroblasts (~ 30 µM) and Hsp70 in HeLa cells. Shown to directly and reversibly interact with cytosolic chaperonin TRiC/CCT subunit (Kd = 613 nM for HSF1A-FITC and Tcp1), involving the hinge 2 region, and destabilize TRiC/CCT-HSF1 association. However, it does not perturb ATP hydrolysis. Reduces protein misfolding and cell death in PolyQ-expressing neuronal precursor cells and protects against cytotoxicity in Drosophila melanogaster model of PolyQ-mediated neurodegeneration.
HSF1 Activator, HSF1A, CAS 1196723-93-9, is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis. Protects cells from polyQ cytotoxicity.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
HSF1
HSF1
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Neef, D.W., et al. 2014. Cell Reports.9, 955.
Neef, D.W., et al. 2010. PLoS Biology.8, e1000291.
Neef, D.W., et al. 2010. PLoS Biology.8, e1000291.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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