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Merck
CN

538925

Prostaglandin I2, Sodium Salt

Potent vasodilatory prostaglandin produced by the endothelium.

Synonym(s):

Prostaglandin I2, Sodium Salt, PGI2, Prostacyclin

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About This Item

Empirical Formula (Hill Notation):
C20H31O5 · Na
CAS Number:
61849-14-7
Molecular Weight:
374.45
UNSPSC Code:
12352211

Key Documents

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Product Name

Prostaglandin I2, Sodium Salt, Potent vasodilatory prostaglandin produced by the endothelium.

InChI key

LMHIPJMTZHDKEW-XQYLJSSYSA-M

InChI

1S/C20H32O5.Na/c1-2-3-4-7-14(21)10-11-16-17-12-15(8-5-6-9-20(23)24)25-19(17)13-18(16)22;/h8,10-11,14,16-19,21-22H,2-7,9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,15-8-;/t14-,16+,17+,18+,19-;/m0./s1

assay

≥98% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: soluble

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Cell permeable: no
Primary Target
Induces vasodilation
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Harmful (C)

General description

Potent vasodilatory prostaglandin produced by the endothelium. Induces vasodilation, stimulates cAMP formation. Cytoprotective and fibrinolytic. Inhibits platelet aggregation by receptor mediated stimulation of adenylate cyclase.

Other Notes

Vane, J.R. 1985. Adv. Prostaglandin Thromboxane Leukotriene Res.15, 11.
Moncada, S., et al. 1979. Pharmacol. Rev.30, 293.
Cho, M.J. and Allen, M.A. 1978. Prostaglandins15, 943.
Tateson, J.E., et al. 1977. Prostaglandins13, 389.

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). This product is rapidly hydrolyzed in acidic solutions. The half-life at pH 7.48 is between 3.5 min and 10.5 min at 25°C. At pH 12 the half-life is ~6 days at 25°C. No loss of biological activity was observed at pH 9.37 for 48 h, when stored at 0°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

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Henrike Hoermann et al.
International journal of molecular sciences, 22(22) (2021-11-28)
Vascular injury induces the exposure of subendothelial extracellular matrix (ECM) important to serve as substrate for platelets to adhere to the injured vessel wall to avoid massive blood loss. Different ECM proteins are known to initiate platelet adhesion and activation.

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