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Sigma-Aldrich

15d-PGJ2

A metabolite of PGD₂that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected NIH/3T3 cells and for PPARγ response element (PPRE) in CV-1 cells.

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Synonym(s):
15d-PGJ2, Prostaglandin J₂, 15-Deoxy-Δ 12,14, PPAR Agonist VII, PPARγ Agonist VI
Empirical Formula (Hill Notation):
C20H28O3
CAS Number:
87893-55-8
Molecular Weight:
316.43
MDL number:
MFCD00065806

Quality Level

100

Assay

≥95% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

solubility

DMSO: 25 mg/mL
ethanol: 25 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C20H28O3/c1-2-3-4-5-6-10-13-18-17(15-16-19(18)21)12-9-7-8-11-14-20(22)23/h6-7,9-10,13,15-17H,2-5,8,11-12,14H2,1H3,(H,22,23)/b9-7-,10-6+,18-13+/t17-/m0/s1

InChI key

VHRUMKCAEVRUBK-GODQJPCRSA-N

General description

A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.

Biochem/physiol Actions

Cell permeable: no
Primary Target
A natural ligand for PPARγ-dependent adipogenesis
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Petrova, T.V., et al. 1999. Proc. Natl. Acad. Sci. USA96, 4668.
Ricote, M., et al. 1998. Nature 391, 79.
Forman, B.M., et al. 1995. Cell 83, 803.
Kliewer, S.A., et al. 1995. Cell83, 813.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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