539163-M
Proteasome Inhibitor III
The Proteasome Inhibitor III controls the biological activity of Proteasome. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
Synonym(s):
Proteasome Inhibitor III, MG-262, Z-LLL-B(OH)₂
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About This Item
Empirical Formula (Hill Notation):
C25H42BN3O6
CAS Number:
Molecular Weight:
491.43
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
DMSO: 5 mg/mL
storage temp.
−20°C
InChI
1S/C25H42BN3O6/c1-16(2)12-20(24(31)29-22(26(33)34)14-18(5)6)27-23(30)21(13-17(3)4)28-25(32)35-15-19-10-8-7-9-11-19/h7-11,16-18,20-22,33-34H,12-15H2,1-6H3,(H,27,30)(H,28,32)(H,29,31)/t20-,21-,22-/m0/s1
InChI key
MWKOOGAFELWOCD-FKBYEOEOSA-N
General description
A boronic acid-based, reversible proteasome inhibitor that is structurally similar to MG-132 (Cat. No. 474790) but displays much higher potency (Ki = 0.03 nM versus 4 nM for MG-132).
Biochem/physiol Actions
Target Ki: 30 pM against proteasome
Preparation Note
Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Other Notes
Adams, J., et al. 1998. Bioorg. Med. Chem. Lett. 8, 333.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
Mc Cormack, T., et al. 1997. J. Biol. Chem. 272, 26103.
Z-Leu-Leu-Leu-B(OH)₂
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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