552233
QX-314
≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem®
Synonym(s):
QX-314
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About This Item
Empirical Formula (Hill Notation):
C16H27BrN2O
CAS Number:
Molecular Weight:
343.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99%
Form:
lyophilized solid
Quality level:
Storage condition:
OK to freeze, protect from light
Product Name
QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.
Quality Level
assay
≥99%
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
solubility
water: 3 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[N+](CC)(CC)(CC)CC(=O)Nc1c(cccc1C)C
InChI
1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1
InChI key
PYEBKOFMWAMBFV-UHFFFAOYSA-O
General description
A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Biochem/physiol Actions
Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing
Other Notes
Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Charlie H T Kwok et al.
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Increased afferent input resulting from painful injury augments the activity of central nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident immune cells of the central nervous system (CNS), play a crucial role in the pathogenesis of chronic pain.
Michael G Frantz et al.
Current biology : CB, 30(15), 2962-2973 (2020-06-27)
Disrupting binocular vision during a developmental critical period can yield enduring changes to ocular dominance (OD) in primary visual cortex (V1). Here we investigated how this experience-dependent plasticity is coordinated within the laminar circuitry of V1 by deleting separately in
Emmanuel L Crespo et al.
STAR protocols, 2(3), 100667-100667 (2021-07-22)
Bioluminescent optogenetics (BL-OG) allows activation of photosensory proteins, such as opsins, by either fiberoptics or by administering a luciferin. BL-OG thus confers both optogenetic and chemogenetic access within the same genetically targeted neuron. This bimodality offers a powerful approach for
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 552233-100MG | 04055977268331 |