552233
QX-314
≥99% (HPLC), lyophilized solid, voltage-sensitive Na+ conductance blocker, Calbiochem®
Synonym(s):
QX-314
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C16H27BrN2O
CAS Number:
Molecular Weight:
343.30
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99%
Form:
lyophilized solid
Storage condition:
OK to freeze, protect from light
Product Name
QX-314, A quaternary lidocaine derivative, permanently charged, and lipophobic.
Quality Segment
assay
≥99%
form
lyophilized solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
solubility
water: 3 mg/mL
shipped in
ambient
storage temp.
10-30°C
SMILES string
[N+](CC)(CC)(CC)CC(=O)Nc1c(cccc1C)C
InChI
1S/C16H26N2O/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5/h9-11H,6-8,12H2,1-5H3/p+1
InChI key
PYEBKOFMWAMBFV-UHFFFAOYSA-O
General description
A quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
Biochem/physiol Actions
Cell permeable: no
Primary Target
A powerful blocker of voltage-sensitive Na+ conductance
A powerful blocker of voltage-sensitive Na+ conductance
Product does not compete with ATP.
Reversible: no
fully active in neurophysiological testing
Other Notes
Mooney, R. 1992. J. Neurosci.12, 2464.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Regehr, W.G. and Tank, D.W. 1992. J. Neurosci.12, 4202.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 552233-100MG | 04055977268331 |