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About This Item
Empirical Formula (Hill Notation):
C15H8Br2INO2
CAS Number:
Molecular Weight:
520.94
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.28
Quality Level
Assay
≥97% (HPLC)
form
solid
potency
9 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
dark orange
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
Ic1cc2c(cc1)NC(=O)\C\2=C/c3cc(c(c(c3)Br)O)Br
InChI
1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChI key
LMXYVLFTZRPNRV-KMKOMSMNSA-N
General description
A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CRAFI kinase
CRAFI kinase
Product competes with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
From Catalog:
Desc. Field- added "Predicted broad spectrum antitumor agents."
From Catalog:
Desc. Field- added "Predicted broad spectrum antitumor agents."
Other Notes
Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett.10, 223.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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