553008
Raf1 Kinase Inhibitor I
The Raf1 Kinase Inhibitor I, also referenced under CAS 220904-83-6, controls the biological activity of Raf1 Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
别名:
Raf1 Kinase Inhibitor I, 5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone, GW 5074
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关于此项目
经验公式（希尔记法）:
C15H8Br2INO2
化学文摘社编号:
分子量:
520.94
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
SMILES string
Ic1cc2c(cc1)NC(=O)\C\2=C/c3cc(c(c(c3)Br)O)Br
InChI
1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChI key
LMXYVLFTZRPNRV-KMKOMSMNSA-N
assay
≥97% (HPLC)
form
solid
potency
9 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
dark orange
solubility
DMSO: 200 mg/mL
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50 = 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 µg/96 µl) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
CRAFI kinase
CRAFI kinase
Product competes with ATP.
Reversible: yes
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
From Catalog:
Desc. Field- added "Predicted broad spectrum antitumor agents."
From Catalog:
Desc. Field- added "Predicted broad spectrum antitumor agents."
Other Notes
Lackey, K., et al. 2000. Bioorg. Med. Chem. Lett.10, 223.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
存储类别
11 - Combustible Solids
wgk
WGK 3
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