553014
Raf Kinase Inhibitor IV
The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Raf Kinase Inhibitor IV, 2-(Phenyl)-4-(3-hydroxy-4-chlorophenyl)-5-(4-pyridyl)-1H-imidazole, L 779450
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About This Item
Product Name
Raf Kinase Inhibitor IV, The Raf Kinase Inhibitor IV, also referenced under CAS 303727-31-3, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
SMILES string
Clc1c(cc(cc1)c2nc([nH]c2c4ccncc4)c3ccccc3)O
InChI
1S/C20H14ClN3O/c21-16-7-6-15(12-17(16)25)19-18(13-8-10-22-11-9-13)23-20(24-19)14-4-2-1-3-5-14/h1-12,25H,(H,23,24)
InChI key
WXJLXRNWMLWVFB-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
solid
potency
10 nM IC50
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
off-white
solubility
ethanol: 10 mg/mL
DMSO: 100 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
Related Categories
Biochem/physiol Actions
Raf Kinase
Disclaimer
General description
Other Notes
Shelton, J.G., et al. 2003. Leukemia17, 1765.
Packaging
Legal Information
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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Related Content
Human Kinome Poster: The InhibitorSelect™ Protein Kinase Inhibitor Libraries provide broad coverage of the human kinome as shown here. The depicted human kinome dendrogram of 518 kinases are classified into five broad groups, 90 families, and 145 subfamilies. Inhibitor coverage was assigned based upon published data related to potency (IC50, EC50, Kd, etc.) for individual kinases harvested from the literature. Colored dots denote which library contains an inhibitor with demonstrated potent activity against the designated kinase and do not necessarily reflect known specificity of the inhibitor. Coverage of lipid and atypical kinases are depicted as a separate dendrogram. As shown, Calbiochem® Protein Kinase Inhibitor Libraries cover all major kinase families including TK, CMGC, CAMK, AGC, CK1, STE, TKL, as well as Lipid or Atypical kinase families.
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