553018-M
RAF Kinase Inhibitor VII
Synonym(s):
RAF Kinase Inhibitor VII, 1-(4-(2,3-Dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
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About This Item
Empirical Formula (Hill Notation):
C21H15ClF3N5O3S
CAS Number:
Molecular Weight:
509.89
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
OK to freeze, protect from light
assay
≥98% (HPLC)
Quality Segment
form
powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
caramel
solubility
DMSO: 50 mg/mL
storage temp.
−20°C
General description
A cell-permeable imidazopyridinyl-urea compound that acts as a potent inhibitor against B-RafV600E activity (IC50 = 1 nM) by targeting its ATP-binding pocket and the adjacent lipophilic allosteric site accessible only when the enzyme is in its inactive DFG-out conformation. Reported to effectively inhibit RafV600E-dependent ERK phosphorylation (IC50 = 610 nM) and growth of human melanoma WM266.4 cells (GI50 = 470 nM).
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Menard, D., et al. 2009. J. Med. Chem.52, 3881.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Regulatory Review (Z)
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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