555554
Rho Kinase Inhibitor IV
The Rho Kinase Inhibitor IV controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
Synonym(s):
Rho Kinase Inhibitor IV, (S)-(+)-2-Methyl-4-glycyl-1-(4-methylisoquinolinyl-5-sulfonyl)homopiperazine, 2HCl, H-1152, Glycyl
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About This Item
Empirical Formula (Hill Notation):
C18H24N4O3S · 2HCl · xH2O
Molecular Weight:
449.40 (anhydrous basis)
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
Quality Level
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic), protect from light
color
pale yellow
solubility
water: 1 mg/mL, DMSO: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
General description
A cell-permeable, reversible, and ATP-comptetive glycyl analog of Rho-Kinase Inhibitor (Cat. No. 555550) that inhibits ROCK with an improved selectivity (IC50 = 11.8 nM, >10 µM, >10 µM, 3.26 µM, 2.35 µM, and 2.57 µM for ROCKII, PKA, PKC, PKG, Aurora A, and CaMKII, respectively).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
ROCK II
ROCK II
Product competes with ATP.
Reversible: yes
Target IC50: 11.8 nM against ROCK II
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Tamura, M., et al. 2005. Biochim. Biophys. Acta, 1754, 245.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 555554-1MG | 04055977268447 |