主要文件

查看所有文档

555554

Rho Kinase Inhibitor IV

Name: Rho Kinase Inhibitor IV
Brand: MM

The Rho Kinase Inhibitor IV controls the biological activity of Rho Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

别名:

Rho Kinase Inhibitor IV, (S)-(+)-2-Methyl-4-glycyl-1-(4-methylisoquinolinyl-5-sulfonyl)homopiperazine, 2HCl, H-1152, Glycyl

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₁₈H₂₄N₄O₃S · 2HCl · xH₂O

分子量:

449.40 (anhydrous basis)

UNSPSC Code:

12352200

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

pale yellow

solubility

water: 1 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

说明

General description

A cell-permeable, reversible, and ATP-comptetive glycyl analog of Rho-Kinase Inhibitor (Cat. No. 555550) that inhibits ROCK with an improved selectivity (IC₅₀ = 11.8 nM, >10 µM, >10 µM, 3.26 µM, 2.35 µM, and 2.57 µM for ROCKII, PKA, PKC, PKG, Aurora A, and CaMKII, respectively).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
ROCK II

Product competes with ATP.

Reversible: yes

Target IC₅₀: 11.8 nM against ROCK II

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Tamura, M., et al. 2005. Biochim. Biophys. Acta, 1754, 245.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c