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555558

Rho/SRF Pathway Inhibitor, CCG-1423

Name: Rho/SRF Pathway Inhibitor, CCG-1423
Brand: MM

The Rho/SRF Pathway Inhibitor, CCG-1423, also referenced under CAS 285986-88-1, controls the biological activity of Rho/SRF. This small molecule/inhibitor is primarily used for Cell Structure applications.

Synonym(s):

Rho/SRF Pathway Inhibitor, CCG-1423, N-(2-(4-Chloroanilino)-1-methyl-2-oxoethoxy)-3,5-bis(trifluoromethyl)benzamide, MICAL-2 Inhibitor I, MRTF-A/SRF Transcription Inhibitor I, MLK1/SRF Transcription Inhibitor I

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₃ClF₆N₂O₃

CAS Number:

285986-88-1

Molecular Weight:

454.75

MDL number:

MFCD01566719

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

FC(F)(F)c1cc(cc(c1)C(=O)NOC(C)C(=O)Nc2ccc(cc2)Cl)C(F)(F)F

InChI

1S/C18H13ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9H,1H3,(H,26,28)(H,27,29)

InChI key

DSMXVSGJIDFLKP-UHFFFAOYSA-N

Description

General description

A cell-permeable benzamide compound that acts as an effective inhibitor against RhoA- and RhoC-mediated cellular activities by targeting signaling events downstream of Gα_12/13 and RhoA/C, affecting MKL recruitment and/or postrecruitment function of MKL1, but not SRF-SRE interaction or ROCK kinase activity. CCG-1423 is shown to inhibit RhoC-dependent cell growth in A375M2 and SK-Mel-147 (IC₅₀ ≤300 nM) and block RhoC/ Gα₁₂-mediated PC-13 invasion in Matrigel assays (by ~90% at 3 µM). Shown to inhibit MICAL-2 with a K_i of 1.5 µM.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Lundquist, M.R., et al. 2014. Cell156, 563..
Evelyn, C.R., et al. 2007. Mol. Cancer Ther.6, 2249.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c