557550
Ro106-9920
A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties.
Synonym(s):
Ro106-9920
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About This Item
Empirical Formula (Hill Notation):
C10H7N5OS
CAS Number:
Molecular Weight:
245.26
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated, protect from light
color
white
solubility
ethanol: 1 mg/mL, DMSO: 25 mg/mL
shipped in
wet ice
storage temp.
−70°C
SMILES string
[S](=O)(c3ccccc3)c1n[n]2nnnc2cc1
InChI
1S/C10H7N5OS/c16-17(8-4-2-1-3-5-8)10-7-6-9-11-13-14-15(9)12-10/h1-7H
InChI key
JFSXSNSCPNFCDM-UHFFFAOYSA-N
General description
A cell-permeable tetrazolopyridazine-phenylsulfoxide compound that displays anti-inflammatory properties. Acts as a highly selective, irreversible inhibitor of IκBαee ubiquitination (IC50 = 2.3 µM). Also reported to prevent degradation of IκBαee in MM6 cells (complete inhibition at ~3-5 µM). Shown to block NF-κB-dependent cytokine expression in human peripheral blood mononuclear cells (PBMN) (IC50 = 600-700 nM for TNF-α, IL-1β, and IL-6 inhibition). Also shown to lower circulating levels of TNFα in LPS-treated rats. Also shown to inhibit 5-lipoxygenase (89% inhibition) and EGFR kinase (63% inhibition) at higher concentrations (10 µM).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
IκBαee ubiquitination
IκBαee ubiquitination
Product does not compete with ATP.
Reversible: no
Target IC50: 2.3 µM against IκBαee ubiquitination
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
Other Notes
Swinney, D.C., et al. 2002. J. Biol. Chem.277, 23573.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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