565792-M
γ-Secretase Inhibitor XXIII, Aβ42-Selective
The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.
Synonym(s):
γ-Secretase Inhibitor XXIII, Aβ42-Selective
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About This Item
Empirical Formula (Hill Notation):
C30H39N7O
Molecular Weight:
513.68
UNSPSC Code:
12352203
NACRES:
NA.54
Assay:
≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
beige
solubility
DMSO: 25 mg/mL
storage temp.
2-8°C
General description
A cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Other Notes
Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett.20, 2279.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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