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565851

NSC-87877

Name: NSC-87877
Brand: MM

≥97% (HPLC), solid, SHP1/2 PTPase inhibitor, Calbiochem^®

Synonym(s):

SHP1/2 PTPase Inhibitor, NSC-87877, 8-Hydroxy-7-(6-sulfonaphthalen-2-yl)diazenyl-quinoline-5-sulfonic acid, Disodium Salt, HePTP Inhibitor II, PTP Inhibitor XXV, PTP1B Inhibitor IV, SHP1 Inhibitor I, SHP2 Inhibitor I

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₁N₃Na₂O₇S₂

CAS Number:

56932-43-5

Molecular Weight:

503.42

MDL number:

MFCD00041863

UNSPSC Code:

12352200

NACRES:

NA.54

Assay:

≥97% (HPLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Product Name

SHP1/2 PTPase Inhibitor, NSC-87877, The SHP1/2 PTPase Inhibitor, NSC-87877, also referenced under CAS 56932-43-5, controls the biological activity of SHP1/2 PTPase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

red-brown

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[Na+].[Na+].[S](=O)(=O)([O-])c1cc2c(cc(cc2)N\N=C3/C=C(c4c(nccc4)C/3=O)[S](=O)(=O)[O-])cc1

InChI

1S/C19H13N3O7S2.2Na/c23-19-16(10-17(31(27,28)29)15-2-1-7-20-18(15)19)22-21-13-5-3-12-9-14(30(24,25)26)6-4-11(12)8-13;;/h1-10,21H,(H,24,25,26)(H,27,28,29);;/q;2*+1/p-2/b22-16+;;

InChI key

YOGRUDWAJPVHEL-LLDDCTHSSA-L

Description

General description

A cell-permeable 7-aza-8-hydroxyquinoline compound that acts as a potent, catalytic site-targeting inhibitor of SHP-1 and SHP-2 protein tyrosine phosphatases (IC₅₀ = 355 nM and 318 nM, respectively). It inhibits PTP1B and HePTP with less potency (IC₅₀ = 1.69 µM and 7.75 µM, respectively) and exhibits >200-fold selectivity over DEP1, CD45, and LAR. Shown to inhibit both basal and stimulated SHP-2 activity in HEK293 cells.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
SHP1/2 PTPase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 355 nM and 318 nM against SHP-1 and SHP-2 protein tyrosine phosphatases, respectively

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chen, L., et al. 2006. Mol. Pharmacol.70, 562.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c