567060
Siomycin A, Streptomyces sioyaensis
A cell-permeable thiostrepton family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis by interfering with rRNA binding.
Synonym(s):
Siomycin A, Streptomyces sioyaensis, NSC 285116, FOXM1 Inhibitor II
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About This Item
Empirical Formula (Hill Notation):
C71H81N19O18S5
Molecular Weight:
1648.84
UNSPSC Code:
12352200
Assay:
≥95% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 10 mg/mL
shipped in
wet ice
storage temp.
−20°C
General description
A cell-permeable thiostrepton family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 M), phosphorylation, as well as mRNA (>60% reduction at 10 M) and protein (>90% reduction at 20 M) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Priller, M., et al. 2011. Clin. Cancer Res.17, 6791.
Radhakrishnan, S.K., et al. 2006. Cancer Res.66, 9731.
Erdal, H., et al. Proc. Natl. Acad. Sci. USA102, 192.
Lentzen, G., et al. 2003. Chem. Biol.10, 769.
Radhakrishnan, S.K., et al. 2006. Cancer Res.66, 9731.
Erdal, H., et al. Proc. Natl. Acad. Sci. USA102, 192.
Lentzen, G., et al. 2003. Chem. Biol.10, 769.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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