572635
SU6656
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor.
Synonym(s):
SU6656
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C19H21N3O3S
CAS Number:
Molecular Weight:
371.45
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
burnt orange
solubility
DMSO: 25 mg/mL
shipped in
ambient
storage temp.
−20°C
SMILES string
[S](=O)(=O)(N(C)C)c1cc2c(cc1)NC(=O)\C\2=C\c3[nH]c4c(c3)CCCC4
InChI
1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)/b16-10+
InChI key
LOGJQOUIVKBFGH-MHWRWJLKSA-N
General description
A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC50 = 280 nM) as well as closely related kinases such as Fyn (IC50 = 170 nM) and Yes (IC50 = 20 nM) and Lyn (IC50 = 130 nM). Acts as a weak inhibitor of Lck (IC50 = 688 µM) and PDGF receptor kinase (IC50 >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.
Biochem/physiol Actions
Cell permeable: yes
Product competes with ATP.
Reversible: yes
Target IC50: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.
Packaging
Packaged under inert gas
Other Notes
Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Still not finding the right product?
Explore all of our products under SU6656
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Related Content
Ning Wu et al.
Cell reports, 30(4), 1129-1140 (2020-01-30)
Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external injury to the plasma membrane. To
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 572635-1MG | 04055977266290 |