SU11652

A cell-permeable pyrrole-indolinone compound that acts as a potent, reversible, and ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFRβ (IC₅₀ = 3 nM), VEGFR2 (IC₅₀ = 27 nM), FGFR1 (IC₅₀ = 170 nM), and Kit family members (IC₅₀ = ~ 10-500 nM) over EGFR (IC₅₀ >20 µM). Reported to display anti-proliferative and pro-apoptotic properties in tumor cells.

A cell-permeable, potent, reversible, and ATP-competitive inhibitor of tyrosine kinase activity of PDGFRβ (IC₅₀ = 3 nM), VEGFR2 (IC₅₀ = 27 nM), FGFR1 (IC₅₀ = 170 nM), and Kit family members (IC₅₀ ~10-500 nM). Does not effect the activity of EGFR (IC₅₀ >20 µM). Reported to display anti-proliferative, antiangiogenic and pro-apoptotic properties in tumor cells.

Cell permeable: yes

Primary Target
PDGFRB

Product competes with ATP.

Reversible: yes

Target IC₅₀: 3 nM, 27 nM, 170 nM against PDGFRβ, VEGFR2, and FGFR1, respectively

Packaged under inert gas

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Heryanto, B., et al. 2003. Reproduction125, 334.
Sun, L., et al. 2003. J. Med. Chem.46, 1116.
Liao, A.T., et al. 2002. Blood100, 585.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Toxicity: Standard Handling (A)