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573132-M

STAT3 Inhibitor XVIII, BP-1-102

Name: STAT3 Inhibitor XVIII, BP-1-102
Brand: MM

The STAT3 Inhibitor XVIII, BP-1-102 controls the biological activity of STAT3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

STAT3 Inhibitor XVIII, BP-1-102, 4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid

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About This Item

Empirical Formula (Hill Notation):

C₂₉H₂₇F₅N₂O₆S

CAS Number:

1334493-07-0

Molecular Weight:

626.59

MDL number:

MFCD29477477

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

powder

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

white

solubility

DMSO: 100 mg/mL

storage temp.

2-8°C

SMILES string

Fc1c(c(c(c(c1F)F)[S](=O)(=O)N(CC(=O)N(Cc3ccc(cc3)C4CCCCC4)c2cc(c(cc2)C(=O)O)O)C)F)F

InChI

1S/C29H27F5N2O6S/c1-35(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)15-22(38)36(19-11-12-20(29(39)40)21(37)13-19)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-13,17,37H,2-6,14-15H2,1H3,(H,39,40)

InChI key

WNVSFFVDMUSXSX-UHFFFAOYSA-N

Description

General description

A cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (K_D = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC₅₀ = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.

Biochem/physiol Actions

Primary Target
Stat3

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, X., et al. Proc. Natl. Acad. Sci. USA109, 9623.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c