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574711

Syk Inhibitor

Name: Syk Inhibitor
Brand: MM

The Spleen Tyrosine Kinase Inhibitor, also referenced under CAS 622387-85-3, controls the biological activity of Spleen Tyrosine Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

Syk Inhibitor, Spleen Tyrosine Kinase Inhibitor, 3-(1-Methyl-1H-indol-3-yl-methylene)-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₈H₁₅N₃O₃S

CAS Number:

622387-85-3

Molecular Weight:

353.40

MDL number:

MFCD07776820

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (sum of two isomers, HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥97% (sum of two isomers, HPLC)

form

solid

potency

14 nM IC₅₀

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

deep orange

solubility

DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N)c1cc2c(cc1)NC(=O)C2=Cc3c4c([n](c3)C)cccc4

InChI

1S/C18H15N3O3S/c1-21-10-11(13-4-2-3-5-17(13)21)8-15-14-9-12(25(19,23)24)6-7-16(14)20-18(15)22/h2-10H,1H3,(H,20,22)(H2,19,23,24)

InChI key

MLKHXLFEYOOYEY-UHFFFAOYSA-N

Description

General description

A cell-permeable oxindole compound that acts as a potent, reversible, and ATP-competitive Syk inhibitor (IC₅₀ = 14 nM). Has been shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM).

A cell-permeable, potent, reversible, and ATP-competitive Spleen Tyrosine Kinase (Syk) inhibitor (IC₅₀ = 14 nM). Shown to effectively inhibit FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3 (EC₅₀ = 313 nM).

Biochem/physiol Actions

Cell permeable: yes

EC50 = 313 nM against FcεRI-mediated degranulation in the rat basophilic leukemia cell line, RBL-2H3

Product competes with ATP.

Reversible: yes

Packaging

Packaged under inert gas

Other Notes

Lai, J.Y.Q., et al. 2003. Bioorg. Med. Chem. Lett.13, 3111.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c