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574714

BAY 61-3606

≥97% (HPLC), solid, Syk inhibitor, Calbiochem®

Synonym(s):

Syk Inhibitor IV, BAY 61-3606, 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

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About This Item

Empirical Formula (Hill Notation):
C20H18N6O3 · xHCl · yH2O
CAS Number:
732983-37-8
Molecular Weight:
390.40 (anhydrous free base basis)
MDL number:
MFCD18641826
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light
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Product Name

Syk Inhibitor IV, BAY 61-3606, The Syk Inhibitor IV, BAY 61-3606, also referenced under CAS 732938-37-8, controls the biological activity of Syk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Quality Segment

100

assay

≥97% (HPLC)

form

solid

potency

10 nM IC50

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

yellow

solubility

DMSO: 10 mg/mL, water: 20 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[n]21c(ncc2)cc(nc1Nc4ncccc4C(=O)N)c3cc(c(cc3)OC)OC

InChI

1S/C20H18N6O3/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20(24-14)25-19-13(18(21)27)4-3-7-23-19/h3-11H,1-2H3,(H2,21,27)(H,23,24,25)

InChI key

JWQOJVOKBAAAAR-UHFFFAOYSA-N

General description

A cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Syk
Product competes with ATP.
Reversible: yes

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Yamamoto, N., et al. 2003. J. Pharm. Exp. Ther.306, 1174.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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