574775-M
Swainsonine, Swainsona canescens
Reversible active-site inhibitor of lysosomal α-mannosidase.
Synonym(s):
Swainsonine, Swainsona canescens, (1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
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About This Item
Empirical Formula (Hill Notation):
C8H15NO3
CAS Number:
Molecular Weight:
173.21
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.77
Assay:
≥98% (TLC)
Form:
solid
Storage condition:
OK to freeze
Quality Segment
assay
≥98% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
color
white
solubility
water: 1 mg/mL, DMSO: 5 mg/mL, chloroform: soluble
storage temp.
2-8°C
SMILES string
N21[C@@H]([C@@H]([C@@H](C2)O)O)[C@@H](CCC1)O
InChI
1S/C8H15NO3/c10-5-2-1-3-9-4-6(11)8(12)7(5)9/h5-8,10-12H,1-4H2/t5-,6-,7-,8-/m1/s1
InChI key
FXUAIOOAOAVCGD-WCTZXXKLSA-N
General description
Reversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
Biochem/physiol Actions
Primary Target
Lysosomal α-mannosidase
Lysosomal α-mannosidase
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Other Notes
Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
Elbein, A.D. 1983. Methods Enzymol.98, 135.
Elbein, A.D. 1983. Methods Enzymol.98, 135.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
Certificates of Analysis (COA)
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