580560
TCEP, Hydrochloride
A water-soluble and odorless disulfide-reducing agent that is more stable and effective than DTT.
Synonym(s):
TCEP, Hydrochloride, tris(2-Carboxyethyl)phosphine, HCl
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Empirical Formula (Hill Notation):
C9H15O6P · xHCl
CAS Number:
Molecular Weight:
250.19 (free base basis)
UNSPSC Code:
12352128
NACRES:
NA.25
MDL number:
Assay:
≥98% (elemental analysis)
Form:
crystalline solid
Quality Level
assay
≥98% (elemental analysis)
form
crystalline solid
reaction suitability
reagent type: reductant
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated
color
white
solubility
water: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
P(CCC(=O)[O-])(CCC(=O)[O-])CCC(=O)[O-]
InChI
1S/C9H15O6P/c10-7(11)1-4-16(5-2-8(12)13)6-3-9(14)15/h1-6H2,(H,10,11)(H,12,13)(H,14,15)/p-3
InChI key
PZBFGYYEXUXCOF-UHFFFAOYSA-K
General description
A water-soluble and odorless disulfide reducing agent which is more stable and effective than DTT. TCEP reduces even the most stable water-soluble alkyl disulfides at pH 4.5 within 5 min. TCEP is also capable of functioning as a reducing agent even in pH range of 1.5-8.5. Is more resistant to air-oxidation as compared to DTT.
Application
- Peptide and Protein Desulfurization with Diboron Reagents.: This study investigates the use of TCEP hydrochloride in peptide and protein desulfurization, demonstrating its effectiveness in facilitating diboron-mediated reactions. (Jing & Walczak, 2024).
- A Study on Thiol-Michael Addition to Semi-Synthetic Elastin-Hyaluronan Material for Electrospun Scaffolds.: TCEP hydrochloride is utilized to enhance the thiol-Michael addition reaction in the development of electrospun scaffolds, contributing to advanced biomaterials research. (Laezza et al., 2024).
- Optimized total RNA isolation from bovine sperm with enhanced sperm head lysis.: This paper presents an optimized protocol for RNA isolation from bovine sperm, highlighting the role of TCEP hydrochloride in improving sperm head lysis efficiency. (Tiwari et al., 2024).
- Target Recognition-Triggered Peroxidase-Mimicking Activity Depression in Homochiral Nanochannels for Identifying Cystine Enantiomers.: The study uses TCEP hydrochloride in a novel peroxidase-mimicking system to differentiate cystine enantiomers, showcasing its application in chiral analysis. (Xu et al., 2023).
- In situ digestion of alcohol-fixed cells for quantitative proteomics.: TCEP hydrochloride is applied in the in situ digestion of fixed cells to enhance the accuracy of quantitative proteomics analyses. (Hatano et al., 2023).
Packaging
Packaged under inert gas
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Corrosive (L)
signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 580560-1GM | 07790788051846 |