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581500

TEMPOL

≥95% (HPLC), crystals,powder, free radical scavenger and nitric oxide spin trap, Calbiochem®

Synonym(s):

TEMPOL, 4-Hydroxy-TEMPO, 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl

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About This Item

Empirical Formula (Hill Notation):
C9H18NO2
CAS Number:
2226-96-2
Molecular Weight:
172.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00006478
Assay:
≥95% (HPLC)
Form:
crystals, powder
Storage condition:
OK to freeze, protect from light
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Product Name

TEMPOL, A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap.

Quality Segment

100

description

RTECS - TN8991000

assay

≥95% (HPLC)

form

crystals, powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, protect from light

color

orange

solubility

DMSO: 5 mg/mL, ethanol: soluble, water: soluble

shipped in

ambient

storage temp.

−20°C

SMILES string

[N+]1(C(CC(CC1(C)C)O)(C)C)[O-]

InChI

1S/C9H18NO2/c1-8(2)5-7(11)6-9(3,4)10(8)12/h7,11H,5-6H2,1-4H3

InChI key

UZFMOKQJFYMBGY-UHFFFAOYSA-N

General description

A stable, cell-permeable nitroxide free radical that acts as a radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.
A stable, cell-permeable nitroxide that acts as a free radical scavenger and nitric oxide spin trap. Induces oxidative stress and enhances the levels of p21WAF1 in HL-60 cells in a dose-dependent manner. Reported to reduce organ injury following hemorrhagic shock. Exhibits radio-protective and anti-proliferative properties.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Free radical scavenger and nitric oxide spin trap
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Preparation Note

Prepare fresh solutions. Following reconstitution, aliquot and freeze (-20°C).

Other Notes

Gariboldi, M.B., et al. 2000. Free Radic. Biol. Med.29, 633.
Miura, Y., et al. 2000. J. Radiat. Res. (Tokyo)41, 103.
Mota-Filipe, H., et al. 1999. Shock 12, 255.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2 Oral

target_organs

Liver,spleen

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

294.8 °F - DIN 51758

flash_point_c

146 °C - DIN 51758

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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