582000
Anti-Telomerase (Ab-1) Rabbit pAb
liquid, Calbiochem®
Synonym(s):
Anti-TERT-1
isotype
IgG
biological source
rabbit
antibody product type
primary antibodies
clone
polyclonal
form
liquid
does not contain
preservative
species reactivity
human, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
shipped in
wet ice
storage temp.
−20°C
Quality Level
General description
Rabbit polyclonal antibody supplied as undiluted serum. Recognizes the ~125 kDa telomerase (TERT) protein.
Recognizes the ~125 kDa telomerase (TERT) protein.
This Anti-Telomerase (Ab-1) Rabbit pAb is validated for use in Immunoblotting, Immunoprecipitation, Paraffin Sections for the detection of Telomerase (Ab-1).
Immunogen
Human
a synthetic peptide corresponding to amino acids from an internal region of the catalytic subunit of human telomerase reverse transcriptase (hTERT)
Application
Immunoblotting (1:100, see comments)
Immunoprecipitation (1:40, see comments)
Paraffin Sections (1:250-1:1000, see comments)
Immunoprecipitation (1:40, see comments)
Paraffin Sections (1:250-1:1000, see comments)
Physical form
Undiluted serum.
Preparation Note
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Antibody works only weakly in paraffin-embedded tissue sections. Nuclear extracts are recommended for immunoblotting and immunoprecipitation. Variables associated with assay conditions will dictate the optimal working dilution.
Fu, W., et al. 2000. J. Mol. Neurosci. 14, 3.
Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.
Kharbanda, S., et al. 2000. Curr. Biol. 10, 568.
Vaziri, H., et al. 1999. Mol. Cell. Biol. 19, 2373.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Daisuke Ogawa et al.
Circulation research, 98(7), e50-e59 (2006-03-25)
Activation of the peroxisome proliferator-activated receptor (PPAR) gamma, the molecular target for insulin sensitizing thiazolidinediones used in patients with type 2 diabetes, inhibits vascular smooth muscle cell (VSMC) proliferation and prevents atherosclerosis and neointima formation. Emerging evidence indicates that telomerase
Sheeba Jacob et al.
Cancer biology & therapy, 17(4), 439-448 (2016-03-24)
Telomerase activation is one of the key mechanisms that allow cells to bypass replicative senescence. Telomerase activity is primarily regulated at the level of transcription of its catalytic unit- hTERT. Prostate cancer (PCa), akin to other cancers, is characterized by
Eva-Maria Fabricius et al.
International journal of oncology, 35(6), 1377-1394 (2009-11-04)
In previous studies we demonstrated telomerase activity in frozen tissues from BCC and their tumor-free margins by the PCR ELISA. In this study we examined in the same frozen sections immunohistochemical presence of hTERT in the nucleus. After fixation in
Awad Shamma et al.
Cancer cell, 15(4), 255-269 (2009-04-07)
Oncogene-induced cellular senescence is well documented, but little is known about how infinite cell proliferation induced by loss of tumor suppressor genes is antagonized by cellular functions. Rb heterozygous mice generate Rb-deficient C cell adenomas that progress to adenocarcinomas following
Peixin Huang et al.
Oncotarget, 6(13), 10812-10824 (2015-05-01)
Aging is the predominant risk factor for cardiovascular diseases and contributes to a considerably more severe outcome in patients with acute myocardial infarction. Resveratrol, a polyphenol found in red wine, is a caloric restriction mimetic with potential anti-aging properties which
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