582231
Tetanus Toxoid
from Clostridium tetani, , lyophilized, nontoxic antigenic agent, Calbiochem®
Synonym(s):
TTx
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About This Item
UNSPSC Code:
12352200
NACRES:
NA.77
Product Name
Tetanus Toxoid, Clostridium tetani, This tetanus toxoid is prepared by formaldehyde inactivation of tetanus toxin. It retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
solubility
soluble (Reconstitute in 50 µl of sterile distilled H2O)
shipped in
ambient
storage temp.
2-8°C
General description
Tetanus Toxoid belongs to the vaccine class of medications. Useful for immunization against tetanus and wound prophylaxis. Non-toxic as determined by an LD50 assay in mice.
Application
Tetanus Toxoid, Clostridium tetani has been used: as a positive-control antigen used to assess antibodies against different SARS-CoV-2 proteins and peptides in patients; to assess lymphocyte proliferation in rabbit PBMC cultures in response to recall antigen stimulation; a stimulus for PBMCs from chronic HBV carrier donors in a T cell proliferation assay
Biochem/physiol Actions
Tetanus Toxoid acts against Clostridium tetani, a gram-positive bacillus that produces a neurotoxin called tetanospasmin. Tetanospasmin prevents the release of an inhibitory neurotransmitter and causes unopposed muscle contractions and spasms. Tetanus toxoid vaccine stimulates the immune system to respond to the vaccine’s antigens. The immune system’s T-lymphocytes (TH2 and B cells) secrete immunoglobulin against the antigen in the vaccine. This immunoglobulin helps to protect against future infections.
Features and Benefits
- Prepared by formaldehyde inactivation of tetanus toxin.
- Prepared by formaldehyde inactivation of tetanus toxin.
- Toxoid retains its antigenic character, but is essentially nontoxic as determined by an LD50 in mice.
- Cell permeable: no
- Product does not compete with ATP.
- Reversible: no
Physical form
Lyophilized from 100 mM histidine, 100 mM NaCl, 5% trehalose, pH 7.0.
Preparation Note
Reconstitute in 50 µl of sterile distilled H₂O
Other Notes
Wrenger, S., et al. 2000. J. Biol. Chem.275, 22180.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Habermann E. and Goretzki, K. 1985. In Monoclonal Antibodies Against Bacteria (Macario, A.J.L., and Conway de Macario, E. eds.) Academic Press, New York, p.191.
Kozbor, D. and Roder, J.C. 1981. J. Immunol.127, 1275.
Bizzini, B., et al. 1970. Eur. J. Biochem.17, 100.
Largier, J.F. and Joubert, F.J. 1956. Biochem. Biophys. Acta20, 407.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品-Merck
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Allan Ma et al.
Human vaccines & immunotherapeutics, 16(4), 756-778 (2019-11-07)
In chronic Hepatitis B Virus (HBV) infections HBV-specific T cells are functionally impaired. Immunotherapy may restore HBV-specific T cell responses essential for sustained disease remission off-treatment and induction of a functional cure. Chimigen® Molecules are fusion proteins of antigen(s) with
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 582231-25UG | 04055977265675 |