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Merck
CN

6.08101

Tetrahydrofuran

suitable for chromatography

Synonym(s):

Tetrahydrofuran, THF, Butylene oxide, Oxolane, Tetramethylene oxide

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
UNSPSC Code:
12352005
Beilstein/REAXYS Number:
102391
MDL number:
MFCD00005356

Key Documents

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Quality Level

100

vapor pressure

114 mmHg ( 15 °C), 143 mmHg ( 20 °C)

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

suitability

suitable for chromatography

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General description

Tetrahydrofuran(THF) is commonly used as a solvent in liquid chromatography. THF is widelyutilized as a solvent in non-aqueous size-exclusion chromatography (SEC),because it is a good solvent for various polymer types.

Application

Tetrahydrofuran can be used as a mobile-phase component in the:
  • Analysis of tocopherols.
  • HPLC analysis of self-associated cationicpolymer (NREP).

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system, Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-6.2 °F - closed cup

flash_point_c

-21.2 °C - closed cup

Regulatory Information

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Certificates of Analysis (COA)

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The thermodynamic properties of tetrahydrofuran-water association and its influence on retention in liquid chromatography
Scott RPW
Journal of Liquid Chromatography and Related Technologies, 23(10), 3083-3093 (2000)
Organic solvent modifier and temperature effects in non-aqueous size-exclusion chromatography on reversed-phase columns
Caltabiano AM, et al.
Journal of Chromatography A, 1531, 83-103 (2018)
The drop-in-drop encapsulation in chitosan and sodium alginate as a method of prolonging the quality of linseed oil
Mania S, et al.
Polymer, 10(12), 1355-1355 (2018)
Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil
Menjoge AR, et al.
Biomacromolecules, 8(2), 532-542 (2007)

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