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6.08101

Sigma-Aldrich

Tetrahydrofuran

for chromatography

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Synonym(s):
Tetrahydrofuran, Butylene oxide, Oxolane, Tetramethylene oxide
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
109-99-9
Molecular Weight:
72.11
Beilstein:
102391
MDL number:
MFCD00005356

grade

for chromatography

Quality Level

100

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

refractive index

n20/D 1.407 (lit.)

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

General description

Tetrahydrofuran(THF) is commonly used as a solvent in liquid chromatography. THF is widelyutilized as a solvent in non-aqueous size-exclusion chromatography (SEC),because it is a good solvent for various polymer types.

Application

Tetrahydrofuran can be used as a mobile-phase component in the:
  • Analysis of tocopherols.
  • HPLC analysis of self-associated cationicpolymer (NREP).

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

Supplementary Hazards

EUH019

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Regulatory Information

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The thermodynamic properties of tetrahydrofuran-water association and its influence on retention in liquid chromatography
Scott RPW
Journal of Liquid Chromatography and Related Technologies, 23(10), 3083-3093 (2000)
Organic solvent modifier and temperature effects in non-aqueous size-exclusion chromatography on reversed-phase columns
Caltabiano AM, et al.
Journal of Chromatography A, 1531, 83-103 (2018)
The drop-in-drop encapsulation in chitosan and sodium alginate as a method of prolonging the quality of linseed oil
Mania S, et al.
Polymer, 10(12), 1355-1355 (2018)
Designing a self-associated cationic polymer for enhanced compatibility, palatability, and gastric release of cefuroxime axetil
Menjoge AR, et al.
Biomacromolecules, 8(2), 532-542 (2007)

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