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Merck
CN

613551

TMEM16A Inhibitor, T16Ainh-A01

The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.

Synonym(s):

TMEM16A Inhibitor, T16Ainh-A01, ANO1 Inhibitor, T16Ainh-A01, 2-(5-ethyl-4-hydroxy-6-methylpyrimidin-2-ylthio)-N-(4-(4-methoxyphenyl)thiazol-2-yl)acetamide, TMEM16A antagonist, T16Ainh-A01

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About This Item

Empirical Formula (Hill Notation):
C19H20N4O3S2
CAS Number:
552309-42-9
Molecular Weight:
416.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD03278952

Key Documents

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Product Name

TMEM16A Inhibitor, T16Ainh-A01, The TMEM16A Inhibitor, T16Ainh-A01 controls the biological activity of TMEM16A.

SMILES string

[s]1c(nc(c1)c3ccc(cc3)OC)NC(=O)CSc2[nH][c](c(c(n2)C)CC)=O

InChI

1S/C19H20N4O3S2/c1-4-14-11(2)20-18(23-17(14)25)28-10-16(24)22-19-21-15(9-27-19)12-5-7-13(26-3)8-6-12/h5-9H,4,10H2,1-3H3,(H,20,23,25)(H,21,22,24)

InChI key

QSIYTNYMBWYHAA-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

off-white

solubility

DMSO: 100 mg/mL, clear, colorless

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Disclaimer

Toxicity: Standard Handling (A)

Other Notes

Davis, A.J., et al. 2012 Br. J. Pharmacol.,in press
Namkung, W., et al. 2011., J Biol Chem. in press.
Namkung, W., et al. 2011., FASEB J. in press.

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

General description

An aminophenylthiazole that acts as an inhibitor of TMEM16A channel, a calcium-activated chloride channel (CaCC) (IC50 = 1.1 µM). Fully blocks CaCC current in salivary gland cells at 10 µM, but has very little effect in airway and intestinal cells, which is consistent with the observation of RNAi knock-down. Completely blocks chloride currents produced by TMEM16A Activator, Eact (Cat. No. 631547 ) at 10 µM. In addition, shown to block calcium-activated chloride channels in vascular smooth muscle cells, and relaxes murine and human blood vessels.

flash_point_f

Not applicable

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Proceedings of the National Academy of Sciences of the USA, 119, e2202490119-e2202490119 (2023)

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