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613560

TMPyP4

Name: TMPyP4
Brand: MM

≥90% (TLC), solid, telomerase inhibitor, Calbiochem^®

Synonym(s):

TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate

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About This Item

Empirical Formula (Hill Notation):

C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄

CAS Number:

36951-72-1

Molecular Weight:

1363.60

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00013468

Assay:

≥90% (TLC)

Form:

solid

Storage condition:

OK to freeze, desiccated (hygroscopic), protect from light

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Properties

Product Name

TMPyP4, A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

Quality Segment

100

assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

purple

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3

InChI key

AKZFRMNXBLFDNN-UHFFFAOYSA-K

Description

General description

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.5 µM inhibiting human telomerase

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c