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TMPyP4

Name: TMPyP4
Brand: MM

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM).

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Synonym(s):

TMPyP4, meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate

Empirical Formula (Hill Notation):

C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄

CAS Number:

36951-72-1

Molecular Weight:

1363.60

MDL number:

MFCD00013468

Quality Level

100

Assay

≥90% (TLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

purple

solubility

water: 1 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C44H37N8.4C7H8O3S/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31;4*1-6-2-4-7(5-3-6)11(8,9)10/h5-28H,1-4H3,(H,45,46,47,48);4*2-5H,1H3,(H,8,9,10)/q+3;;;;/p-3

InChI key

AKZFRMNXBLFDNN-UHFFFAOYSA-K

General description

A potent inhibitor of human telomerase (IC₅₀ = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces highly in the presence of quadruplex DNA.

Biochem/physiol Actions

Cell permeable: no

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 6.5 µM inhibiting human telomerase

Warning

Toxicity: Standard Handling (A)

Other Notes

Yamashita, T., et al. 2005. Bioorg. Med. Chem.13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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