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Merck
CN

616387

Nα-Tosyl-Phe Chloromethyl Ketone

Irreversible inhibitor of chymotrypsin.

Synonym(s):

Nα-Tosyl-Phe Chloromethyl Ketone, TPCK

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About This Item

Empirical Formula (Hill Notation):
C17H18ClNO3S
CAS Number:
402-71-1
Molecular Weight:
351.85
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD00000935

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Product Name

Nα-Tosyl-Phe Chloromethyl Ketone, Irreversible inhibitor of chymotrypsin.

SMILES string

[S](=O)(=O)(N[C@@H](Cc2ccccc2)C(=O)CCl)c1ccc(cc1)C

InChI

1S/C17H18ClNO3S/c1-13-7-9-15(10-8-13)23(21,22)19-16(17(20)12-18)11-14-5-3-2-4-6-14/h2-10,16,19H,11-12H2,1H3/t16-/m0/s1

InChI key

MQUQNUAYKLCRME-INIZCTEOSA-N

description

RTECS - XT5613500

assay

≥98% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

ethanol: 5 mg/mL
methanol: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

Quality Level

100

Related Categories

Biochem/physiol Actions

Cell permeable: no
EC50 = 20 µM in blocking the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides.
Primary Target
chymotrypsin activity in preparations
Product does not compete with ATP.
Reversible: no

Disclaimer

Toxicity: Irritant (B)

General description

Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharide (EC50 = 20 µM). Suggested working concentration is 10-100 µM.
This product has been discontinued.


Irreversible inhibitor of chymotrypsin. Useful for inhibiting chymotrypsin activity in trypsin preparations. Inhibits apoptosis in thymocytes. Blocks the induction of nitric oxide synthase by γ-interferon and lipopolysaccharides (EC50 = 20 M).

Other Notes

Fearnhead, H.O., et al. 1995. FEBS Lett. 357, 242.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun.215, 721.
Weaver, V.M., et al. 1993. Biochem. Cell Biol.71, 488.
Murakami, T., et al. 1991. Biochim. Biophys. Acta1079, 279.
Nierodzik, M.L., et al. 1991. J. Clin. Invest.87, 229.
Wilson, W.E., et al. 1989. J. Biol. Chem. 264, 17777.

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 4 months at 4°C.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

CorrosionExclamation mark
GHS05,GHS07

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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