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616520

TRPV4 Antagonist I, RN-1734

Name: TRPV4 Antagonist I, RN-1734
Brand: MM

The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is primarily used for Biochemicals applications.

Synonym(s):

TRPV4 Antagonist I, RN-1734, 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I, RN1734, RN1734, 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide, Transient Receptor Potential Vanilloid-4 Antagonist I

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About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₂Cl₂N₂O₂S

CAS Number:

946387-07-1

Molecular Weight:

353.31

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00129453

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze, protect from light

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Properties

Quality Segment

100

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 50 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

[S](=O)(=O)(N(C(C)C)CCNC(C)C)c1c(cc(cc1)Cl)Cl

InChI

1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3

InChI key

IHYZMEAZAIFMTN-UHFFFAOYSA-N

Description

General description

A cell-permeable benzenesulfonamide compound that selectively antagonizes TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca²⁺ influx (IC₅₀ = 2.3, 3.2 and 5.9 µM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC₅₀ >30 µM).

Packaging

Packaged under inert gas

Other Notes

Vincent, F., et al. 2009. Biochem. Biophys. Res. Commun.389, 490.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

nwg

flash_point_f

Not applicable

flash_point_c