647950-M
Triclosan
A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fabl encoded enoyl-acyl carrier protein (ACP) reductase.
Synonym(s):
Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol
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About This Item
Empirical Formula (Hill Notation):
C12H7Cl3O2
CAS Number:
Molecular Weight:
289.54
UNSPSC Code:
12352200
MDL number:
Quality Segment
assay
≥97% (HPLC)
form
crystalline powder, powder
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL, ethanol: 50 mg/mL
storage temp.
−20°C
InChI
1S/C12H7Cl3O2/c13-7-1-3-11(9(15)5-7)17-12-4-2-8(14)6-10(12)16/h1-6,16H
InChI key
XEFQLINVKFYRCS-UHFFFAOYSA-N
General description
A potent antimicrobial agent that inhibits bacterial fatty acid synthesis by selectively targeting Fab l encoded enoyl-acyl carrier protein (ACP) reductase. A slow binding inhibitor that forms a stable ternary complex (bsFabl.NAD+. triclosan) in Bacillus subtilis. Also inhibits the growth of Plasmodium falciparum by inhibiting the apicomplexan Fab I (IC50 = 154.4 ng/ml for W2 strain and 387 ng/ml for D6 strain).
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
McLeod, R., et al. 2001. Int. J. Parasitology31, 109.
Surolia, N. and Surolia, A., 2001. Nat. Medicine7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem.275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem.274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol.181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature394, 531.
Surolia, N. and Surolia, A., 2001. Nat. Medicine7, 167.
Heath, R.J., et al. 2000. J. Biol. Chem.275, 4654.
Heath, R.J., et al. 1999. J. Biol. Chem.274, 11110.
Hoang, T.T. and Schweizer, H.P. 1999. J. Bacteriol.181, 5489.
Heath, R.J., et al. 1998. J. Biol. Chem. 273, 30316.
McMurray, L.M., et al. 1998. Nature394, 531.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Environmental Hazard (N)
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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