648485-M
TrpA1 Antagonist, HC-030031
The TrpA1 Antagonist, HC-030031, also referenced under CAS 349085-38-7, controls the biological activity of TrpA1. This small molecule/inhibitor is primarily used for Neuroscience applications.
Synonym(s):
TrpA1 Antagonist, HC-030031, HC-030031
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About This Item
Empirical Formula (Hill Notation):
C18H21N5O3
CAS Number:
Molecular Weight:
355.39
UNSPSC Code:
12352200
MDL number:
NACRES:
NA.51
Assay:
≥98% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
Quality Segment
assay
≥98% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white
solubility
DMSO: 50 mg/mL, clear, colorless
storage temp.
2-8°C
SMILES string
[n]2(c3c(nc2)N(C(=O)N(C3=O)C)C)CC(=O)Nc1ccc(cc1)C(C)C
InChI
1S/C18H21N5O3/c1-11(2)12-5-7-13(8-6-12)20-14(24)9-23-10-19-16-15(23)17(25)22(4)18(26)21(16)3/h5-8,10-11H,9H2,1-4H3,(H,20,24)
InChI key
HEQDZPHDVAOBLN-UHFFFAOYSA-N
General description
A cell-permeable and selective TRPA1 antagonist that reversibly antagonizes AITC- and formalin-evoked calcium influx (IC50 = 6.2 µM and 5.3 µ M, respectively), and blocks AITC- and formalin-induced inward and outward currents in TRPA1-expressing HEK293 cells in a patch-clamp assay. It demonstrates activity towards rat and mouse TRPA1 orthologues, but does not block currents mediated by TRPV1, TRPV3, TRPV4, hERG, or NaV1.2 channels. This compound is also shown to block TRPA1 activation induced by formalin in cultured rat DRG neurons, and attenuate pain-related responses to formalin in rats (300 mg/kg, i.p.), in vivo.
Other Notes
Taylor-Clark, T., et al. 2008. Mol. Pharmacol.73, 274.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A.104, 13525.
McNamara, C., et al. 2007. Proc. Natl. Acad. Sci. U S A.104, 13525.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
No data available
flash_point_c
No data available
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 648485-10MG | 04055977185058 |