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About This Item
Empirical Formula (Hill Notation):
C14H10O
CAS Number:
Molecular Weight:
194.23
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.77
Quality Level
Assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
brown
solubility
DMSO: 50 mg/mL
shipped in
wet ice
storage temp.
2-8°C
SMILES string
Oc1c2c(c3c(c1)cccc3)cccc2
InChI
1S/C14H10O/c15-14-9-10-5-1-2-6-11(10)12-7-3-4-8-13(12)14/h1-9,15H
InChI key
DZKIUEHLEXLYKM-UHFFFAOYSA-N
General description
A cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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