654164
Tubulin Polymerization Inhibitor II
The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.
Synonym(s):
Tubulin Polymerization Inhibitor II, (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one
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About This Item
Empirical Formula (Hill Notation):
C19H19NO5
CAS Number:
Molecular Weight:
341.36
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Assay:
≥97% (HPLC)
Form:
solid
Quality level:
Storage condition:
OK to freeze, protect from light
Quality Level
assay
≥97% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
yellow
solubility
DMSO: 10 mg/mL
shipped in
ambient
storage temp.
2-8°C
SMILES string
N1c2c(ccc(c2)OC)C(=Cc3cc(c(c(c3)OC)OC)OC)C1=O
InChI
1S/C19H19NO5/c1-22-12-5-6-13-14(19(21)20-15(13)10-12)7-11-8-16(23-2)18(25-4)17(9-11)24-3/h5-10H,1-4H3,(H,20,21)
InChI key
YLUHXAHNPQALMQ-UHFFFAOYSA-N
General description
A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested).
Biochem/physiol Actions
Cell permeable: yes
Primary Target
Purified porcine brain tubulin
Purified porcine brain tubulin
Product does not compete with ATP.
Reversible: no
Target IC50: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492.
Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.
Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Harmful (C)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 654164-5MG | 04055977184587 |