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654164

Tubulin Polymerization Inhibitor II

Name: Tubulin Polymerization Inhibitor II
Brand: MM

The Tubulin Polymerization Inhibitor II, also referenced under CAS 1151995-69-5, acts as an effective anti-microtubule agent. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

Tubulin Polymerization Inhibitor II, (E)-1,3-Dihydro-6-methoxy-3-(3,4,5-trimethoxybenzylidene)-1H-indol-2-one

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关于此项目

经验公式（希尔记法）:

C₁₉H₁₉NO₅

化学文摘社编号:

1151995-69-5

分子量:

341.36

MDL number:

MFCD28138101

UNSPSC Code:

12352202

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

Quality Level

100

assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

yellow

solubility

DMSO: 10 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

N1c2c(ccc(c2)OC)C(=Cc3cc(c(c(c3)OC)OC)OC)C1=O

InChI

1S/C19H19NO5/c1-22-12-5-6-13-14(19(21)20-15(13)10-12)7-11-8-16(23-2)18(25-4)17(9-11)24-3/h5-10H,1-4H3,(H,20,21)

InChI key

YLUHXAHNPQALMQ-UHFFFAOYSA-N

说明

General description

A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC₅₀ = 4.5 µM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI₅₀<10 nM for 46 lines among a 53 NCI panel tested).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
Purified porcine brain tubulin

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 4.5 µM in inhibiting polymerization of purified porcine brain tubulin

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pandit, B., et al. 2006. Bioorg. Med. Chem.14, 6492.
Li, P.K., et al. 2005. Bioorg. Med. Chem. Lett.15, 5382.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c