654255
TNF-α Antagonist
≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem®
Synonym(s):
TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I
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About This Item
Empirical Formula (Hill Notation):
C58H71N11O15S2
Molecular Weight:
1226.38
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
lyophilized
Quality level:
Storage condition:
OK to freeze, desiccated (hygroscopic)
Product Name
TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.
Quality Level
assay
≥95% (HPLC)
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, desiccated (hygroscopic)
solubility
water: 1 mg/mL, 5% acetic acid: 5 mg/mL
shipped in
ambient
storage temp.
−20°C
General description
An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.
Biochem/physiol Actions
Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM as TNF-α antagonist
Other Notes
H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.
Legal Information
Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 654255-1MG | 04055977184624 |