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Merck
CN

654255

TNF-α Antagonist

≥95% (HPLC), lyophilized, TNF-α antagonist, Calbiochem®

Synonym(s):

TNF-α Antagonist, TNF Antagonist, WP9QY, Tumor Necrosis Factor Antagonist, TNF-TNFR Signaling Inhibitor I

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About This Item

Empirical Formula (Hill Notation):
C58H71N11O15S2
Molecular Weight:
1226.38
UNSPSC Code:
12352200
NACRES:
NA.77

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Product Name

TNF-α Antagonist, The TNF-α Antagonist controls the biological activity of TNF-α.

Quality Level

100

Assay

≥95% (HPLC)

form

lyophilized

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)

solubility

water: 1 mg/mL
5% acetic acid: 5 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

An exocyclic peptidomimetic that acts as a TNF-α antagonist (IC50 = 5 µM) in binding assay. Blocks TNF-α-mediated apoptosis in mouse L929 cells. Exhibits about twofold higher activity than other known WP5 binding site derived mimetics. Designation WP9QY arises from the binding to the WP9 binding site of the TNF-β/TNF-receptor(I) complex as template, and the introduction of amino acids, Gln and Tyr.

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no
Target IC50: 5 µM as TNF-α antagonist

Other Notes

H-Tyr-Cys-Trp-Ser-Gln-Tyr-Leu-Cys-Tyr-OH (disulfide bond: 2 → 8)
Takasaki, W., et al. 1997. Nat. Biotechnol. 15, 1266.

Legal Information

Sold under license of U.S. Patent 6,265,535.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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