658390
AG 9 - CAS 2826-26-8 - Calbiochem
Synonym(s):
[(4-Methoxybenzylidene)malononitrile, α-Cyano-(4-methoxy)cinnamonitrile], Tyrphostin A1
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About This Item
UNSPSC Code:
12352200
assay
≥98% (TLC)
Quality Segment
form
solid
color
yellow
solubility
ethanol: 10 mg/mL, DMSO: soluble, acetic acid: soluble
General description
An inactive compound that can be used as a negative control for inhibition of EGFR (IC50 >1250 μM for EGFR kinase). Has been shown to inhibit IL-2 stimulated Tyk-2 phosphorylation in ConA-activated T cells.
Biochem/physiol Actions
negative control for inhibition of EGFR
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
Target IC<SUB>50</SUB>:>1250 μM for EGFR kinase
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Storage Class
10-13 - German Storage Class 10 to 13
Regulatory Information
监管及禁止进口产品
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H Ruetten et al.
British journal of pharmacology, 122(1), 59-70 (1997-09-23)
1 Here we compared the effects of various inhibitors of the activity of protein tyrosine kinase on (i) the expression of the activity of the inducible isoform of nitric oxide (NO) synthase (iNOS) caused by endotoxin (lipopolysaccharide, LPS) in cultured
J J Bright et al.
Journal of immunology (Baltimore, Md. : 1950), 162(10), 6255-6262 (1999-05-07)
IL-12 is a macrophage-derived cytokine that induces proliferation, cytokine production, and cytotoxic activity of T and NK cells. Signaling through its receptor, IL-12 induces these cellular responses by tyrosine phosphorylation and activation of Janus kinase-2 (Jak-2), Tyk-2, Stat3, and Stat4.
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors