658460
AG 879 - CAS 148741-30-4 - Calbiochem
A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation.
Synonym(s):
AG 879 - CAS 148741-30-4 - Calbiochem, α-Cyano-(3,5-di- t-butyl-4-hydroxy)thiocinnamide
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About This Item
Empirical Formula (Hill Notation):
C18H24N2OS
CAS Number:
Molecular Weight:
316.46
UNSPSC Code:
12352200
MDL number:
Quality Segment
assay
≥95% (HPLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
orange-yellow
solubility
DMSO: 100 mg/mL, acetic acid: soluble, methanol: soluble
shipped in
ambient
storage temp.
−20°C
InChI
1S/C18H24N2OS/c1-17(2,3)13-8-11(7-12(10-19)16(20)22)9-14(15(13)21)18(4,5)6/h7-9,22H,20H2,1-6H3/b16-12+
InChI key
LCUMYVYIHXYBIA-FOWTUZBSSA-N
General description
A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation (EC50 = 10 µM) as well as NGF-induced phospholipase C-γ1 phosphorylation. Also blocks NGF-induced neurite outgrowth in PC12 cells. Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Inhibits insulin secretion in a dose-dependent manner.
A cell-permeable, reversible, and substrate competitive inhibitor of nerve growth factor (NGF)-dependent pp140c-trk tyrosine phosphorylation (EC50 = 10 µM), as well as NGF-induced phospholipase C-γ1 phosphorylation. Also shown to inhibit HER2 (IC50 = 1 µM). Does not affect the tyrosine phosphorylation of epidermal growth factor receptor or platelet-derived growth factor receptor. Also inhibits insulin secretion in a dose-dependent manner.
Biochem/physiol Actions
Cell permeable: yes
EC50 = 10 µM inhibiting nerve growth factor (NGF)-dependent p140c-trk tyrosine phosphorylation
Primary Target
(NGF)-dependent p140c-trk tyrosine phosphorylation
(NGF)-dependent p140c-trk tyrosine phosphorylation
Product does not compete with ATP.
Reversible: yes
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
From Catalog:
Solubility- removed acetic acid, MeOH
From Catalog:
Solubility- removed acetic acid, MeOH
Other Notes
Konrad, R.J., et al. 1996. J. Biol. Chem. 271, 24179.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.
Levitzki, A. and Gazit, A. 1995. Science. 267, 1782.
Ohmichi, M., et al. 1993. Biochemistry32, 4650.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)
Storage Class
10-13 - German Storage Class 10 to 13
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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