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Merck
CN

681636-M

W-13, Hydrochloride

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 58 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM).

Synonym(s):

W-13, Hydrochloride, N-(4-Aminobutyl)-5-chloro-2-naphthalenesulfonamide, HCl

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About This Item

Empirical Formula (Hill Notation):
C14H17ClN2O2S · xHCl
CAS Number:
88519-57-7
Molecular Weight:
312.81 (free base basis)
UNSPSC Code:
12352200
MDL number:
MFCD00058030
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze, desiccated (hygroscopic), protect from light

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SMILES string

[S](=O)(=O)(NCCCCN)c1cc2c(c(ccc2)Cl)cc1.Cl

InChI

1S/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H

InChI key

QKAALLVQBOLELJ-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze, desiccated (hygroscopic), protect from light

color

white

solubility

water: 35 mg/mL

Quality Level

100

storage temp.

2-8°C

Related Categories

General description

A cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 68 µM) and myosin light chain kinase (IC50 = 58 µM).

Biochem/physiol Actions

Target IC50: 58 µM, 68 µM, against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase

Analysis Note

single spot by TLC

Other Notes

Hidaka, H., and Tanaka, T. 1983. Methods Enzymol. 102, 185.
Tanaka, T., et al. 1983. Pharmacol.26, 249.
Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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