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About This Item

Empirical Formula (Hill Notation):
C24H19ClN2O3
CAS Number:
622855-50-9
Molecular Weight:
418.87
MDL number:
MFCD28138108
UNSPSC Code:
12352200
NACRES:
NA.77
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Quality Level

100

Assay

≥97% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

brown

solubility

DMSO: 10 mg/mL
ethanol: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

SMILES string

Clc1c(cccc1)c2c3c(c4c([n](c5c4cc(cc5)O)CCCC)c2)[c]([nH][c]3=O)=O

InChI

1S/C24H19ClN2O3/c1-2-3-10-27-18-9-8-13(28)11-16(18)20-19(27)12-15(14-6-4-5-7-17(14)25)21-22(20)24(30)26-23(21)29/h4-9,11-12,28H,2-3,10H2,1H3,(H,26,29,30)

InChI key

HLSZACLAFZWCCS-UHFFFAOYSA-N

General description

A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).

Biochem/physiol Actions

Cell permeable: no
Primary Target
Wee1
Product does not compete with ATP.
Reversible: no
Target IC50: 59 nM against Wee1

Packaging

Packaged under inert gas

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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