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8.02540

Cobalt(II) chloride anhydrous

for synthesis

Synonym(s):

Cobalt(II) chloride anhydrous, Cobalt dichloride

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About This Item

Empirical Formula (Hill Notation):
Cl2Co
CAS Number:
7646-79-9
Molecular Weight:
129.84
UNSPSC Code:
12352302
EC Index Number:
231-589-4
NACRES:
NA.22
MDL number:
MFCD00010938
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grade

anhydrous

Quality Level

200

form

powder

potency

418 mg/kg LD50, oral (Rat)

mp

735 °C

solubility

soluble 585.9 g/L

density

3.36 g/cm3 at 25 °C

storage temp.

2-30°C

SMILES string

[Co+2].[Cl-].[Cl-]

InChI

1S/2ClH.Co/h2*1H;/q;;+2/p-2

InChI key

GVPFVAHMJGGAJG-UHFFFAOYSA-L

Application

Cobalt(II) chloride anhydrous (CoCl2) can be used as a catalyst in organic synthesis for the transformation of the various functional groups. For example, synthesis of esters via cleavage of ethers by acyl chlorides; acylation of alcohols and amines by anhydrides; and regioselective cleavage of oxiranes. It is also used to synthesize mixed acetals by the addition reaction between alcohols and vinyl ethers.
CoCl2 can be used as a catalyst:
  • For the dealkylation of tertiary amines.
  • In the synthesis of thioketones and thioaldehydes via thionation of carbonyl compounds in the presence of bis(trimethylsilyl) sulfide.
  • In the oxidation of aromatic and aliphatic aldehydes to carboxylic acids in the presence of molecular oxygen and acetic anhydride.
  • In the stereoselective opening of epoxides with N-substituted anilines.

CoCl2 can also be used as:
  • A precursor to synthesize magnetic cobalt nanorods via decomposition of the cobalt coordination complex.
  • A catalyst to prepare acid anhydrides by the reaction of acid chlorides with carboxylic acids.
  • A reagent in the carbon-carbon bond-forming reactions involving active methylene compounds.

Analysis Note

Assay (argentometric): ≥ 98.0 %
Water (K. F.): ≤ 2.0 %

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B Inhalation - Eye Dam. 1 - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

危险化学品

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Cobalt (II) chloride catalyzed syntheses of acid anhydrides from acid chlorides
Srivastava RR and Kabalka GW
Tetrahedron Letters, 33(5) (1992)
Synthesis and magnetic properties of Co nanorod superlattices
Wetz F, et al.
Materials Science and Engineering, C, 27(5-8) (2007)
Cobalt (II) Chloride
Periasamy M, et al.
eEROS (Encyclopedia of Reagents for Organic Synthesis) (2001)

Global Trade Item Number

SKUGTIN
802540001004027269276645
802540010004022536374048
802540002504022536374031