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8.04515

Sigma-Aldrich

1,1,1,3,3,3-Hexafluoro-2-propanol

for synthesis

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Synonym(s):
1,1,1,3,3,3-Hexafluoro-2-propanol, 1,1,1,3,3,3-Hexafluoroisopropyl alcohol, Hexafluoroisopropanol, HFP
Linear Formula:
CF3CH(OH)CF3
CAS Number:
920-66-1
Molecular Weight:
168.04
MDL number:
MFCD00011651
EC Index Number:
213-059-4

vapor pressure

269 hPa ( 30 °C)

Quality Level

200

form

liquid

potency

1500 mg/kg LD50, oral (Rat)

pH

3-4 ( in H2O, Aqueous solution)

bp

58 °C/1013 hPa

mp

-3 °C

transition temp

flash point >100 °C

density

1.62 g/cm3 at 20 °C

storage temp.

2-30°C

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChI key

BYEAHWXPCBROCE-UHFFFAOYSA-N

Application

1,1,1,3,3,3-Hexafluoro-2-propanol can be used as:
  • A reactant to synthesize hexafluoroisopropyl benzoates by reacting with anthranils and N-alkoxy α-halogenoacetamides.
  • A solvent in the triphosphazene-catalyzed Beckmann rearrangement of ketoximes to lactams.
  • A catalyst to synthesize 2,2-difluoro-3-hydroxy-1,4-diketones via Mukaiyama aldol reaction.

Pictograms

CorrosionHealth hazard
GHS05,GHS08

Signal Word

Danger

Hazard Statements

H314 - H361 - H373

Hazard Classifications

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2

Storage Class Code

8A - Combustible, corrosive hazardous materials

WGK

WGK 2

Flash Point(F)

No data available

Flash Point(C)

No data available

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Ruben Daum et al.
Cells, 9(3) (2020-03-27)
Appropriate mechanical properties and fast endothelialization of synthetic grafts are key to ensure long-term functionality of implants. We used a newly developed biostable polyurethane elastomer (TPCU) to engineer electrospun vascular scaffolds with promising mechanical properties (E-modulus: 4.8 ± 0.6 MPa

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